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Tainted Judas: Starts with the Dark Arts active item instead of the Book of Belial.

However, Tainted Cain can only obtain items through this method.

Tainted Cain: Starts with the Bag of Crafting item, which stores pickups and transforms them into a passive item when used.

Tainted Magdalene: Has a powerful melee attack that triggers when an enemy touches her and leaves a trail behind her that damages enemies, but her health slowly drains down to two red hearts.

Tainted Isaac: Every item pedestal cycles between two options, but you can only hold eight passive items at a time.

They all have varying levels of starting stats and the like, but here are the main things that separate each tainted character from their regular versions. Most of the tainted characters have similar traits to their regular counterparts, but they generally all have an extremely powerful ability balanced by a significant drawback. Take each character through the Ascent to the Home area and use the Red/Cracked Key in the room before Mom's Room to get all the tainted characters. It's certainly a process but, like many things in The Binding of Isaac, you'll find a rhythm as you start working your way through.

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When you are going through the Ascent after finding Dad's Note, you'll take a trip through each boss room you previously visited, but any trinket you've left behind will be transformed into the Cracked Key. You'll either need to carry it to the area or find the Cracked Key item, which is a consumable that has the same effect as the Red Key.Ī good tip for finding the Cracked Key is to drop any trinket item inside a boss room after you've defeated your enemy. Unfortunately, you won't continue to find the Red Key in Mom's Room in later runs. Touch that character to unlock them for future runs. It will open a hidden room with the tainted version of the character you are playing as inside. Go into the hall outside of Mom's Room and use the Red Key. You can now use this item to unlock Tainted Characters. Open the chest here to find the Red Key item, unlocking it for future runs. It isn't randomized like the other areas of The Binding of Isaac, so work your way through the few rooms and you'll get to Mom's Room. Go all the way through the Ascension and you'll reach a new area called Home. You'll find Dad's Note inside this room and you'll begin your ascension. Return to the starting room after defeating the boss, and you'll find a door that can be opened with The Polaroid, The Negative or the Faded Polaroid.

Look for a slightly different skull somewhere in the level and bomb it in order to find a Fool card if you don't have teleportation. To find it, you'll need to defeat the boss and then teleport out of the room.

This is a special item you'll be able to grab in the biome Depths II. You'll need to find Dad's Note on another run.

This is a new boss added to the Repentance DLC, and you'll find her at the end of the Corpse II biome. You'll need to defeat Mother at least once. However, it is time consuming if you want to catch 'em all, and you need to string together a good run in order to reach the point where you can access them. Unlocking tainted characters is simple to explain, as the process is the same for each one.

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Here's how to unlock each tainted character and what makes them special. Even though they look like reskins of Cain, Isaac, Lilith, and the rest, most of them start with new items and abilities, effectively doubling the way you can begin a new run once they're unlocked. Every playable character in The Binding of Isaac: Repentance has a "tainted" version.